Journal Articles

2022

2022 AHA/ACC/HFSA guideline for the management of heart failure. Journal of the American College of Cardiology, 79(17). https://doi.org/10.1016/j.jacc.2021.12.012 Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., Fang, J. C., Fedson, S. E., Fonarow, G. C., Hayek, S. S., Hernandez, A. F., Khazanie, P., Kittleson, M. M., Lee, C. S., Link, M. S., … Yancy, C. W. (2022).

2021

AKI treated with renal replacement therapy in critically ill patients with COVID-19. Journal of the American Society of Nephrology, 32(1), 161–176. https://doi.org/10.1681/asn.2020060897

Gupta, S., Coca, S. G., Chan, L., Melamed, M. L., Brenner, S. K., Hayek, S. S., Sutherland, A., Puri, S., Srivastava, A., Leonberg-Yoo, A., Shehata, A. M., Flythe, J. E., Rashidi, A., Schenck, E. J., Goyal, N., Hedayati, S. S., Dy, R., Bansal, A., Athavale, A., … Leaf, D. E. (2020).

Characteristics and outcomes of individuals with pre-existing kidney disease and covid-19 admitted to Intensive Care Units in the United States. American Journal of Kidney Diseases, 77(2). https://doi.org/10.1053/j.ajkd.2020.09.003

Flythe, J. E., Assimon, M. M., Tugman, M. J., Chang, E. H., Gupta, S., Shah, J., Sosa, M. A., Renaghan, A. D. M., Melamed, M. L., Wilson, F. P., Neyra, J. A., Rashidi, A., Boyle, S. M., Anand, S., Christov, M., Thomas, L. F., Edmonston, D., Leaf, D. E., Walther, C. P., … Hayek, S., Ugwuowo, U. (2021).

Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Intensive Care Medicine, 47(2), 208–221. https://doi.org/10.1007/s00134-020-06331-9

Shaefi, S., Brenner, S. K., Gupta, S., O’Gara, B. P., Krajewski, M. L., Charytan, D. M., Chaudhry, S., Mirza, S. H., Peev, V., Anderson, M., Bansal, A., Hayek, S. S., Srivastava, A., Mathews, K. S., Johns, T. S., Leonberg-Yoo, A., Green, A., Arunthamakun, J., Wille, K. M., … Leaf, D. E. (2021).

Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with COVID-19. Annals of Internal Medicine, 174(5), 622–632. https://doi.org/10.7326/m20-6739

Al-Samkari, H., Gupta, S., Leaf, R. K., Wang, W., Rosovsky, R. P., Brenner, S. K., Hayek, S. S., Berlin, H., Kapoor, R., Shaefi, S., Melamed, M. L., Sutherland, A., Radbel, J., Green, A., Garibaldi, B. T., Srivastava, A., Leonberg-Yoo, A., Shehata, A. M., Flythe, J. E., … Ugwuowo, U. (2021).

Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure. Critical care medicine, 49(7), 1026–1037. https://doi.org/10.1097/CCM.0000000000004938

Mathews, K. S., Soh, H., Shaefi, S., Wang, W., Bose, S., Coca, S., Gupta, S., Hayek, S. S., Srivastava, A., Brenner, S. K., Radbel, J., Green, A., Sutherland, A., Leonberg-Yoo, A., Shehata, A., Schenck, E. J., Short, S., Hernán, M. A., Chan, L., Leaf, D. E., … STOP-COVID Investigators (2021).

2020

In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study BMJ 2020; 371 :m3513

Salim S Hayek, Samantha K Brenner, Tariq U Azam, Husam R Shadid, Elizabeth Anderson, Hanna Berlin, Michael Pan, Chelsea Melcohe, Rafey Feroze, Patrick O'Hayer, Rayan Kaakati, Abbas Bitar, Kishan Padalia, Daniel Perry, Pennelope Blakely, Shruti Gupta, Shahzad Shaefi, Anad Srivastava, David M Carytan, Anip Bansal, Mary Mallappallil, Michal L Melamed, Alexadre M Shehata, Jaf Sunderram, Kusum S Matthews, Anne K Sutherland, Brahmajee K Nallamothu, David E Leaf, on behalf of the STOP-COVID Investigators.


Soluble Urokinase Receptor (SuPAR) in COVID-19–Related AKI. Journal of the American Society of Nephrology, September 2020, ASN.2020060829

Tariq U. Azam, Husam R. Shadid, Pennelope Blakely, Patrick O’Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, Subramaniam Pennathur, Rodica Pop-Busui, Izzet Altintas, Jens Tingleff, Marius A. Stauning, Ove Andersen, Maria-Evangelia Adami, Nicky Solomonidi, Maria Tsilika, Pinkus Tober-Lau, Eleni Arnaoutoglou, Verena Keitel, Frank Tacke, Athanasios Chalkias, Sven H. Loosen, Evangelos J. Giamarellos-Bourboulis, Jesper Eugen-Olsen, Jochen Reiser, Salim S. Hayek and International Study of Inflammation in COVID-19 .


Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Intern Med. Published online July 15, 2020.

Gupta S, Hayek SS, Wang W, et al.


STOP-COVID - Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19 (STOP-COVID)


Management of Cardiovascular Disease During Coronavirus Disease (COVID-19) Pandemic. Trends in Cardiovascular Medicine, 2020.

S Ganatra, SS Dani, S Shah, A Asnani, TG Neilan, D Lenihan, B Ky, A Barac, SS Hayek, M Leja, J Hermann, P Thavendiranathan, M Fradley, V Bang, K Shreyder, R Parikh, R Patel, A Singh, S Brar, A Guha, D Gupta, P Mascari, R Patten, D Venesy, A Nohria, FS Resnic.


Elevated suPAR Is an Independent Risk Marker for Incident Kidney Disease in Acute Medical Patients. Frontiers in Cell and Developmental Biology, 8 339, (2020.)

E Iversen, MB Houlind, T Kallemose, LJH Rasmussen, M Hornum, B Feldt-Rasmussen, SS Hayek, O Andersen, J Eugen-Olsen.

Clinical and Research Tools for the Study of Cardiovascular Effects of Cancer Therapy. J. of Cardiovasc. Trans. Res. 13, 417–430 (2020).

Feroze, R.A., Leya, J., Herron, T. et al.

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia. Critical Care 24, 187 (2020).

Rovina N, Akinosoglou K, Eugen-Olsen J, Hayek S, Reiser J Giamarellos-Bourboulis EJ.

Mitral Regurgitation in Low-Flow, Low-Gradient Aortic Stenosis Patients Undergoing TAVR. J Am Coll Cardiol Intv. 2020 Mar, 13 (5) 567-579.

AB Freitas-Ferraz, S Lerakis, HB Ribeiro, M Gilard, JL Cavalcante, R Makkar, HC Herrmann, S Windecker, M Enriquez-Sarano, AN Cheema, L Nombela-Franco, I Amat-Santos, AJ Muñoz-García, B Garcia del Blanco, A Zajarias, JC Lisko, S Hayek, V Babaliaros, F Le Ven, TG. Gleason, T Chakravarty, WY Szeto, M-A Clavel, A de Agustin, V Serra, JT Schindler, A Dahou, M-S Annabi, E Pelletier-Beaumont, P Pibarot, J Rodés-Cabau.

Evaluating the Relationship Between Quantitative Measures of Myocardial Perfusion and Biomarkers of Myonecrosis, Inflammation, and Vasoconstriction. J Am Coll Cardiol. 2020 Mar, 75 (11 Supplement 1) 1577. Anderson ERP, Patel VN, Pieper JA, Weinberg RL, Ficaro EP, Hayek SS, Shah RV, Konerman MC, Murthy VL.

Sex Differences in Circulating Soluble Urokinase‐Type Plasminogen Activator Receptor (suPAR) Levels and Adverse Outcomes in Coronary Artery Disease. Journal of the American Heart Association. 2020;9. Anurag Mehta MD , Shivang R. Desai MD , Yi‐An Ko PhD , Chang Liu MPH , Devinder S. Dhindsa MD , Aditi Nayak MD , Ananya Hooda MBBS , Mohamed A. Martini MD , Kiran Ejaz MD , Laurence S. Sperling MD , Jochen Reiser MD, PhD , Salim S. Hayek MD , and Arshed A. Quyyumi MD.

Soluble Urokinase Receptor and Acute Kidney Injury. New England Journal of Medicine. 2020; 382:416-426. Hayek SS, Leaf DE, Tahhan AS, Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS-C, Holliday MW, Januzzi JL, Weisbord SD, Quyyumi AA, Reiser J.

2019

Carcinoid Heart Disease: A Guide for Clinicians. Cardiology Clinics. 2019;37(4):497-503. Perry D and Hayek SS.


Soluble Urokinase Plasminogen Activator Receptor and Decline in Kidney Function in Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology. 2019; 30. Hayek SS, Landisttel DP, Wei C, Zeier M, Yu ASL, Torres VE, Roth S, Pao CS, Resier J.

Chimeric Antigen Receptor T-Cell Therapy for Cancer and Heart: JACC Council Perspectives. Journal of the American College of Cardiology, 2019; 74, 25, 3153-3163. S Ganatra, JR Carver, SS Hayek, B Ky, MJ Leja, DJ Lenihan, C Lenneman, N Mousavi, JH Park, MA Perales, TD Ryan, M Scherrer-Crosbie, RM Steingart, EH Yang, V Zaha, A Barac, JE Liu


How to Say Goodbye: Simple Lessons for the Cardiovascular Physician When Faced With Patient Death. Journal of the American College of Cardiology 2019 Jul, 74 (1) 154-156 . SS Hayek.

Low Educational Attainment is a Predictor of Adverse Outcomes in Patients With Coronary Artery Disease. Journal of the American Heart Association. 2019;8. HM Kelli, A Mehta, AS Tahhan , C Liu , JH Kim , TA Dong , DS Dhindsa, B Ghazzal , MK Choudhary , PB Sandesara , SS Hayek, ML Topel , AA Alkhoder, MA Martini, A Sidoti, Y-A Ko, TT Lewis, V Vaccarin , LS Sperling, and AA Quyyumi.

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. The Journal of clinical investigation. 2019; 130. Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J.

Sleep Duration and Mortality in Patients With Coronary Artery Disease. The American journal of cardiology. 2019; 123(6):874-881. Kim JH, Hayek SS, Ko YA, Liu C, Samman Tahhan A, Ali S, Alkhoder A, Gafeer MM, Choudhary F, Bhimani R, Delawalla S, Choudhary M, Hartsfield DJ, Bliwise DL, Quyyumi AA.

Mechanisms underlying the J-curve for diastolic blood pressure: Subclinical myocardial injury and immune activation. International journal of cardiology. 2019; 276:255-260. Topel ML, Sandesara PB, Stahl EP, Hayek SS, Tahhan AS, O'Neal WT, Ko YA, Alkhoder A, Gafeer MM, Kim JH, Wilson PWF, Shaw LJ, Epstein SE, Vaccarino V, Sperling LS, Quyyumi AA.

Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry. JAMA cardiology. 2019; 4(1):64-70. Maes F, Lerakis S, Barbosa Ribeiro H, Gilard M, Cavalcante JL, Makkar R, Herrmann HC, Windecker S, Enriquez-Sarano M, Cheema AN, Nombela-Franco L, Amat-Santos I, Muñoz-García AJ, Garcia Del Blanco B, Zajarias A, Lisko JC, Hayek S, Babaliaros V, Le Ven F, Gleason TG, Chakravarty T, Szeto W, Clavel MA, de Agustin A, Serra V, Schindler JT, Dahou A, Salah-Annabi M, Pelletier-Beaumont E, Côté M, Puri R, Pibarot P, Rodés-Cabau J.

2018

Ibrutinib-Associated Atrial Fibrillation. JACC. Clinical electrophysiology. 2018; 4(12):1491-1500. Ganatra S, Sharma A, Shah S, Chaudhry GM, Martin DT, Neilan TG, Mahmood SS, Barac A, Groarke JD, Hayek SS, Dani S, Venesy D, Patten R, Nohria A.


Mean Aortic pressure gradient and global longitudinal strain recovery after transcatheter aortic valve replacement - A retrospective analysis. Hellenic journal of cardiology. 2018; 59(5):268-271. Corrigan FE, Zhou X, Lisko JC, Hayek SS, Parastatidis I, Keegan P, Howell S, Thourani V, Babaliaros VC, Lerakis S.

Soluble urokinase-type plasminogen activator receptor and incident end-stage renal disease in Chinese patients with chronic kidney disease. Nephrology, dialysis, transplantation. 2018 Aug 13. Lv L, Wang F, Wu L, Wang JW, Cui Z, Hayek SS, Wei C, Reiser J, He K, Zhang L, Chen M, Zhao MH.

Circulating Progenitor Cells and Racial Differences. Circulation research. 2018; 123(4):467-476. Samman Tahhan A, Hammadah M, Kelli HM, Kim JH, Sandesara PB, Alkhoder A, Kaseer B, Gafeer MM, Topel M, Hayek SS, O'Neal WT, Obideen M, Ko YA, Liu C, Hesaroieh I, Mahar E, Vaccarino V, Waller EK, Quyyumi AA.


Soluble Urokinase-Type Plasminogen Activator Receptor in Black Americans with CKD. Clinical journal of the American Society of Nephrology. 2018; 13(7):1013-1021. Luo S, Coresh J, Tin A, Rebholz CM, Chen TK, Hayek SS, Tracy M, Lipkowitz MS, Appel LJ, Levey AS, Inker LA, Reiser J, Grams ME.

Cardio-Oncology for GenNext: A Missing Piece of the Training Puzzle. Journal of the American College of Cardiology. 2018; 71(25):2977-2981. Ganatra S, Hayek SS.