Hayek Lab

Cardiac Biomarkers Laboratory

LATEST UPDATES

September 15, 2021


Kingsley Amadi, a current junior at Michigan State University, joined the Hayek Lab this summer as a laboratory assistant developing ongoing research efforts related to suPAR and the management of multi-vessel coronary artery disease. Patients with this disease generally undergo coronary artery bypass grant (CABG) surgery, yet many of those who do not require a full surgery prefer a less invasive procedure called percutaneous coronary intervention (PCI). Ultimately, this research aims to develop a method in determining whether a patient requires the CABG surgery or the stent procedure.

To work towards this goal, Kingsley’s project focused on understanding the role of suPAR levels as one of the markers of multi-vessel coronary artery disease and deriving appropriate cut-off levels that affect this clinical treatment direction. For this project, the Hayek Lab used samples from BARI-2D, a clinical trial for patients with type 2 diabetes with some cardiac symptoms.

In the lab, Kingsley worked with fellow lab members Chris Launius, Iman Shaikh, and Annika Tekumulla. On a day to day basis, Kingsley tended to the mouse colonies and performed various assays to measure suPAR, 8-isoprostanes, and mouse atherosclerosis biomarkers. Concentration levels of these biomarkers were updated into data sample software Freezerworks and standardized through Softmax Pro computer analysis.

Though the Hayek Lab continues to gather these results, current data has demonstrated suPAR levels ranging from 3 to 6 mg/mL and higher within patients with multi-vessel coronary artery disease, an indication of inflammation. Kingsley remains optimistic about the promising role suPAR plays in disease management and tracking, and the Hayek Lab appreciates his efforts.

Kingsley is now back in East Lansing for the fall semester, and we wish him the best of luck!

The Cardiac Biomarkers lab is a quickly growing lab with both clinical and basic research projects. Our research centers on the novel use of biomarkers for predictive and prevention-based diagnoses and disease treatment. The lab's ultimate goal is to use high-throughput technology to personalize patient care.


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